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This vibrant city, the second largest in Portugal, is world renowned for its Port wine, which can be found and sampled all over the city. Built upon the steep hillsides of the Duoro River, the Romans established a thriving port here almost 2,000 years ago, and subsequent conquests by the Moors and the Christians have left indelible marks on Oporto's architecture and culture. Its historical center, including the 12th century Se fortress cathedral, neoclassical Stock Exchange, and the Church of Santa Clara, is listed as a UNESCO World Heritage Site.